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DeCS
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Descriptor English:
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Ubiquitin-Protein Ligase Complexes
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Descriptor Spanish:
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Complejos de Ubiquitina-Proteína Ligasa
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Descriptor Portuguese:
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Complexos Ubiquitina-Proteína Ligase
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Tree Number:
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D08.811.464.938
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Definition English:
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Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES). |
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Indexing Annotation English:
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UBIQUITIN-PROTEIN LIGASES is also available
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History Note English:
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2004
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Allowable Qualifiers English:
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Record Number:
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38180
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Unique Identifier:
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D043743
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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